Difference between revisions of "Prostate cancer"
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(Created page with "==Links== [http://urology.jhu.edu/prostate/partintables.php Partin tables] to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score") |
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| + | '''Use of this site is subject to you reading and agreeing with the terms set forth in the [[HemOnc.org_-_A_Hematology_Oncology_Wiki:General_disclaimer|disclaimer]].''' | ||
| + | |||
| + | Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are [[How_to_contribute|invited to contribute to the site]]. | ||
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| + | {{TOC limit|limit=3}} | ||
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| + | ==Metastatic castrate-resistant disease== | ||
| + | ===Cabazitaxel (Jevtana)=== | ||
| + | ====Regimen==== | ||
| + | *[[Cabazitaxel (Jevtana)]] 25 mg/m2 IV over 1 hour on day 1 | ||
| + | *[[Prednisone (Sterapred)]] 10 mg PO on days 1-21 | ||
| + | |||
| + | '''21-day cycles x up to 10 cycles''' | ||
| + | |||
| + | Supportive medications: | ||
| + | *"Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel | ||
| + | |||
| + | ====References==== | ||
| + | # de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed] | ||
| + | |||
| + | ===Mitoxantrone (Novantrone)=== | ||
| + | ====Regimen==== | ||
| + | *[[Mitoxantrone (Novantrone)]] 12 mg/m2 IV over 15-30 minutes on day 1 | ||
| + | *[[Prednisone (Sterapred)]] 10 mg PO on days 1-21 | ||
| + | |||
| + | '''21-day cycles x up to 10 cycles''' | ||
| + | |||
| + | ====References==== | ||
| + | # de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed] | ||
| + | |||
==Links== | ==Links== | ||
[http://urology.jhu.edu/prostate/partintables.php Partin tables] to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score | [http://urology.jhu.edu/prostate/partintables.php Partin tables] to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score | ||
Revision as of 06:55, 21 March 2012
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.
Metastatic castrate-resistant disease
Cabazitaxel (Jevtana)
Regimen
- Cabazitaxel (Jevtana) 25 mg/m2 IV over 1 hour on day 1
- Prednisone (Sterapred) 10 mg PO on days 1-21
21-day cycles x up to 10 cycles
Supportive medications:
- "Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel
References
- de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed
Mitoxantrone (Novantrone)
Regimen
- Mitoxantrone (Novantrone) 12 mg/m2 IV over 15-30 minutes on day 1
- Prednisone (Sterapred) 10 mg PO on days 1-21
21-day cycles x up to 10 cycles
References
- de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed
Links
Partin tables to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score