Difference between revisions of "Samarium-153 (Quadramet)"
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Revision as of 02:57, 24 October 2017
General information
Class/mechanism: Radioactive pharmaceutical agent (Samarium-153) that concentrates in areas of bone turnover associated with hydroxyapatite and releases beta and gamma radiation. Samarium-153 accumulates in osteoblastic lesions about 5 times as much as normal bone. Samarium-153's half-life is 46.3 hours.[1][2][3][4][5]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 3/28/1997: Initial FDA approval "for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan."
Also known as
153-Sm-EDTMP, 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP), Lexidronam Pentasodium, Quadramet, Samarium [153 SM], Samarium Sm 153 Lexidronam Injection, samarium Sm 152 oxide, 152Sm2O3.
References
- ↑ 1.0 1.1 Samarium-153 (Quadramet) package insert
- ↑ Samarium-153 (Quadramet) package insert (locally hosted backup)
- ↑ Samarium-153 (Quadramet) alternative package insert
- ↑ Samarium-153 (Quadramet) alternative package insert (locally hosted backup)
- ↑ Quadramet manufacturer's website
- ↑ Samarium-153 (Quadramet) patient drug information (UpToDate)