Class/mechanism: Radioactive pharmaceutical agent (Samarium-153) that concentrates in areas of bone turnover associated with hydroxyapatite and releases beta and gamma radiation. Samarium-153 accumulates in osteoblastic lesions about 5 times as much as normal bone. Samarium-153's half-life is 46.3 hours.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 1997-03-28: Initial approval for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan.
History of changes in EMA indication
- 1998-02-04: Initial authorization
Also known as
- Generic names: 153-Sm-EDTMP, 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP), lexidronam pentasodium, samarium [153 SM], samarium Sm 153 lexidronam injection
- Brand name: Quadramet
- Samarium-153 (Quadramet) package insert
- Samarium-153 (Quadramet) package insert (locally hosted backup)
- Samarium-153 (Quadramet) alternative package insert
- Samarium-153 (Quadramet) alternative package insert (locally hosted backup)
- Quadramet manufacturer's website
- Samarium-153 (Quadramet) patient drug information (UpToDate)