Difference between revisions of "Anal cancer"
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m (moved Anal carcinoma to Anal cancer) |
m (formatting of headers) |
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{{TOC limit|limit=3}} | {{TOC limit|limit=3}} | ||
| − | + | =Chemotherapy & radiation therapy= | |
| − | + | ==Fluorouracil (5-FU), Mitomycin (Mutamycin), radiation therapy== | |
| − | + | ===Regimen=== | |
*[[Fluorouracil (5-FU)]] 1000 mg/m2/day IV continuous infusion on days 1-4 and 29-32 | *[[Fluorouracil (5-FU)]] 1000 mg/m2/day IV continuous infusion on days 1-4 and 29-32 | ||
*[[Mitomycin (Mutamycin)]] 10 mg/m2 (maximum of 20mg per dose) IV bolus on days 1 & 29 | *[[Mitomycin (Mutamycin)]] 10 mg/m2 (maximum of 20mg per dose) IV bolus on days 1 & 29 | ||
*Concurrent radiation therapy; at a minimum: 1.8 Gy per day, 5 days per week; 25 fractions given over 5 weeks total for a total of 45 Gy | *Concurrent radiation therapy; at a minimum: 1.8 Gy per day, 5 days per week; 25 fractions given over 5 weeks total for a total of 45 Gy | ||
| − | + | ===References=== | |
# Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. [http://jama.ama-assn.org/content/299/16/1914.full link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/18430910 PubMed] | # Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. [http://jama.ama-assn.org/content/299/16/1914.full link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/18430910 PubMed] | ||
| − | + | =Chemotherapy= | |
| − | + | ==Fluorouracil (5-FU), Cisplatin (Platinol)== | |
| − | + | ===Regimen=== | |
*[[Fluorouracil (5-FU)]] 1000 mg/m2/day IV continuous infusion on days 1-5 | *[[Fluorouracil (5-FU)]] 1000 mg/m2/day IV continuous infusion on days 1-5 | ||
*[[Cisplatin (Platinol)]] 100 mg/m2 IV on day 2 | *[[Cisplatin (Platinol)]] 100 mg/m2 IV on day 2 | ||
| Line 19: | Line 19: | ||
'''28-day cycles''' | '''28-day cycles''' | ||
| − | + | ===References=== | |
# Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F. [5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer]. [Article in French] Bull Cancer. 1999 Oct;86(10):861-5. [http://www.jle.com/en/revues/medecine/bdc/e-docs/00/01/12/15/resume.phtml link to original article & English summary] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10572237 PubMed] | # Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F. [5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer]. [Article in French] Bull Cancer. 1999 Oct;86(10):861-5. [http://www.jle.com/en/revues/medecine/bdc/e-docs/00/01/12/15/resume.phtml link to original article & English summary] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10572237 PubMed] | ||
Revision as of 03:46, 21 April 2012
Chemotherapy & radiation therapy
Fluorouracil (5-FU), Mitomycin (Mutamycin), radiation therapy
Regimen
- Fluorouracil (5-FU) 1000 mg/m2/day IV continuous infusion on days 1-4 and 29-32
- Mitomycin (Mutamycin) 10 mg/m2 (maximum of 20mg per dose) IV bolus on days 1 & 29
- Concurrent radiation therapy; at a minimum: 1.8 Gy per day, 5 days per week; 25 fractions given over 5 weeks total for a total of 45 Gy
References
- Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. link to original article contains protocol PubMed
Chemotherapy
Fluorouracil (5-FU), Cisplatin (Platinol)
Regimen
- Fluorouracil (5-FU) 1000 mg/m2/day IV continuous infusion on days 1-5
- Cisplatin (Platinol) 100 mg/m2 IV on day 2
28-day cycles
References
- Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F. [5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer]. [Article in French] Bull Cancer. 1999 Oct;86(10):861-5. link to original article & English summary contains protocol PubMed