Difference between revisions of "Anastrozole (Arimidex)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Selective non-steroidal aromatase inhibitor. | + | Class/mechanism: Selective non-steroidal aromatase inhibitor. The aromatase enzyme converts adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) in peripheral tissues.<ref name="insert">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=acbfaaa9-503c-4691-9828-76a7146ed6de Anastrozole (Arimidex) package insert]</ref><ref>[[:File:Anastrozole.pdf | Anastrozole (Arimidex) package insert (locally hosted backup)]]</ref><ref>[http://www.arimidex.com/ Arimidex manufacturer's website]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/arimidex-anastrozole-342208 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Breast cancer]] | *[[Breast cancer]] | ||
| − | *[[ | + | *[[Endometrial cancer]] |
==Patient drug information== | ==Patient drug information== | ||
| − | *[ | + | *[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=acbfaaa9-503c-4691-9828-76a7146ed6de Anastrozole (Arimidex) package insert]<ref name="insert"></ref> |
| − | *[ | + | *[https://chemocare.com/druginfo/anastrozole.aspx Anastrozole (Arimidex) patient drug information (Chemocare)]<ref>[https://chemocare.com/druginfo/anastrozole.aspx Anastrozole (Arimidex) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/anastrozole-patient-drug-information Anastrozole (Arimidex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/anastrozole-patient-drug-information Anastrozole (Arimidex) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/anastrozole-patient-drug-information Anastrozole (Arimidex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/anastrozole-patient-drug-information Anastrozole (Arimidex) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==History of changes in FDA indication== | ||
| + | *1995-12-27: Initial approval for treatment of advanced [[breast cancer]] in postmenopausal women with disease progression following tamoxifen therapy. ''(Based on Buzdar et al. 1996 & Jonat et al. 1996)'' | ||
| + | *2002-09-05: Accelerated approval for adjuvant treatment of postmenopausal women with [[Biomarkers#HR|hormone receptor]]-[[Biomarkers#Normal_expression|positive]] early [[breast cancer]]. ''(Based on ATAC)'' | ||
| + | **2005-09-16: Converted to regular approval for adjuvant treatment of postmenopausal women with [[Biomarkers#HR|hormone receptor]]-[[Biomarkers#Normal_expression|positive]] early [[breast cancer]]. ''(Based on ATAC)'' | ||
| + | *Uncertain date: Approved for first-line treatment of postmenopausal women with [[Biomarkers#HR|hormone receptor]]-[[Biomarkers#Normal_expression|positive]] or [[Biomarkers#HR|hormone receptor]]-[[Biomarkers#Unknown|unknown]] locally advanced or metastatic [[breast cancer]]. ''(Based on Arimidex Study Group 2000 & TARGET<sub>Breast</sub>)'' | ||
| + | ==History of changes in EMA indication== | ||
| + | ''The approval of this drug pre-dates the EMA.'' | ||
| + | *1995-08-11: EURD | ||
| + | ==History of changes in Health Canada indication== | ||
| + | *2004-06-30: Initial notice of compliance with conditions | ||
| + | *2008-12-02: Conditions were met | ||
| + | |||
| + | ==Also known as== | ||
| + | *'''Brand names:''' Altraz, Anabrez, Anastraze, Anastrazol Rontag, Anastrol, Arimidex, Asiolex, Karomex, Leprofen, RUI SI YI, RUI Ting, Trozolet, Trozolite. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| − | [[Category: | + | [[Category:Drugs]] |
| − | [[Category: | + | [[Category:Oral medications]] |
| − | [[Category:Aromatase inhibitors]] | + | [[Category:Protein expression-specific medications]] |
| + | |||
| + | [[Category:Aromatase inhibitors, third generation]] | ||
[[Category:Breast cancer medications]] | [[Category:Breast cancer medications]] | ||
| − | [[Category: | + | [[Category:Endometrial cancer medications]] |
| + | [[Category:FDA approved in 1995]] | ||
| + | [[Category:EMA approved in 1995]] | ||
| + | [[Category:Health Canada approved in 2004]] | ||
| + | [[Category:WHO Essential Cancer Medicine]] | ||
Latest revision as of 15:09, 17 November 2023
General information
Class/mechanism: Selective non-steroidal aromatase inhibitor. The aromatase enzyme converts adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) in peripheral tissues.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Anastrozole (Arimidex) package insert[1]
- Anastrozole (Arimidex) patient drug information (Chemocare)[4]
- Anastrozole (Arimidex) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 1995-12-27: Initial approval for treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. (Based on Buzdar et al. 1996 & Jonat et al. 1996)
- 2002-09-05: Accelerated approval for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. (Based on ATAC)
- 2005-09-16: Converted to regular approval for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. (Based on ATAC)
- Uncertain date: Approved for first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor-unknown locally advanced or metastatic breast cancer. (Based on Arimidex Study Group 2000 & TARGETBreast)
History of changes in EMA indication
The approval of this drug pre-dates the EMA.
- 1995-08-11: EURD
History of changes in Health Canada indication
- 2004-06-30: Initial notice of compliance with conditions
- 2008-12-02: Conditions were met
Also known as
- Brand names: Altraz, Anabrez, Anastraze, Anastrazol Rontag, Anastrol, Arimidex, Asiolex, Karomex, Leprofen, RUI SI YI, RUI Ting, Trozolet, Trozolite.