Difference between revisions of "Classical Hodgkin lymphoma - historical"

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search
Line 139: Line 139:
 
|'''Study'''
 
|'''Study'''
 
|[[Levels_of_Evidence#Evidence|'''Evidence''']]
 
|[[Levels_of_Evidence#Evidence|'''Evidence''']]
 +
|-
 +
|[http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(197806)41:6%3C2107::AID-CNCR2820410606%3E3.0.CO;2-L/abstract Krikorian et al. 1978]
 +
|<span
 +
style="background:#EEEE00;
 +
padding:3px 6px 3px 6px;
 +
border-color:black;
 +
border-width:2px;
 +
border-style:solid;">Phase II</span>
 
|-
 
|-
 
|[http://www.ncbi.nlm.nih.gov/pubmed/93984 Santoro et al. 1979]
 
|[http://www.ncbi.nlm.nih.gov/pubmed/93984 Santoro et al. 1979]
Line 147: Line 155:
 
border-width:2px;
 
border-width:2px;
 
border-style:solid;">Phase II</span>
 
border-style:solid;">Phase II</span>
−
|-
 
−
!colspan="4" align="center"|
 
 
|-
 
|-
 
|[http://annals.org/article.aspx?articleid=698987 Harker et al. 1984]
 
|[http://annals.org/article.aspx?articleid=698987 Harker et al. 1984]
Line 163: Line 169:
  
 
===References===
 
===References===
 +
# Krikorian JG, Portlock CS, Rosenberg SA. Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy. Cancer. 1978 Jun;41(6):2107-11. [http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(197806)41:6%3C2107::AID-CNCR2820410606%3E3.0.CO;2-L/abstract link to original article] [http://www.ncbi.nlm.nih.gov/pubmed/77716 PubMed]
 
# Santoro A, Bonadonna G. Prolonged disease-free survival in MOPP-resistant Hodgkin's disease after treatment with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). Cancer Chemother Pharmacol. 1979;2(2):101-5. [http://www.ncbi.nlm.nih.gov/pubmed/93984 PubMed]
 
# Santoro A, Bonadonna G. Prolonged disease-free survival in MOPP-resistant Hodgkin's disease after treatment with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). Cancer Chemother Pharmacol. 1979;2(2):101-5. [http://www.ncbi.nlm.nih.gov/pubmed/93984 PubMed]
 
# Santoro A, Bonfante V, Bonadonna G. Salvage chemotherapy with ABVD in MOPP-resistant Hodgkin's disease. Ann Intern Med. 1982 Feb;96(2):139-43. [http://annals.org/article.aspx?articleid=695320 link to original article] [http://www.ncbi.nlm.nih.gov/pubmed/6174060 PubMed]
 
# Santoro A, Bonfante V, Bonadonna G. Salvage chemotherapy with ABVD in MOPP-resistant Hodgkin's disease. Ann Intern Med. 1982 Feb;96(2):139-43. [http://annals.org/article.aspx?articleid=695320 link to original article] [http://www.ncbi.nlm.nih.gov/pubmed/6174060 PubMed]

Revision as of 02:42, 29 December 2015

Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. See the Hodgkin lymphoma page for current regimens.

30 regimens on this page
37 variants on this page


Untreated

CVPP

back to top

CVPP: CCNU (Lomustine), Vinblastine, Procarbazine, Prednisone

Regimen

Study Evidence Comparator
Cooper et al. 1980 Phase III MOPP
MVPP

References

  1. Cooper MR, Pajak TF, Nissen NI, Stutzman L, Brunner K, Cuttner J, Falkson G, Grunwald H, Bank A, Leone L, Seligman BR, Silver RT, Weiss RB, Haurani F, Blom J, Spurr CL, Glidewell OJ, Gottlieb AJ, Holland JF. A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease. Cancer. 1980 Aug 15;46(4):654-62. link to original article PubMed

MVPP

back to top

MVPP: Mechlorethamine, Vinblastine, Procarbazine, Prednisone

Regimen

Study Evidence Comparator
Cooper et al. 1980 Phase III CVPP
MOPP

References

  1. Cooper MR, Pajak TF, Nissen NI, Stutzman L, Brunner K, Cuttner J, Falkson G, Grunwald H, Bank A, Leone L, Seligman BR, Silver RT, Weiss RB, Haurani F, Blom J, Spurr CL, Glidewell OJ, Gottlieb AJ, Holland JF. A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease. Cancer. 1980 Aug 15;46(4):654-62. link to original article PubMed

SCAB

back to top

SCAB: Streptozocin, CCNU (Lomustine), Adriamycin (Doxorubicin), Bleomycin

Regimen

Study Evidence
Diggs et al. 1981 Non-randomized

References

  1. Diggs CH, Wiernik PH, Sutherland JC. Treatment of advanced untreated Hodgkin's disease with SCAB--an alternative to MOPP. Cancer. 1981 Jan 15;47(2):224-8. link to original article PubMed
    1. Update: Wiernik PH, Schiffer CA. Long-term follow-up of advanced Hodgkin's disease patients treated with a combination of streptozotocin, lomustine (CCNU), doxorubicin and bleomycin (SCAB). J Cancer Res Clin Oncol. 1988;114(1):105-7. PubMed

Relapsed/Refractory

ABDIC

back to top

ABDIC: Adriamycin (Doxorubicin), Bleomycin, DIC (Dacarbazine), CCNU (Lomustine), Prednisone

Regimen

Study Evidence
Rodgers et al. 1980 Phase II

References

  1. Rodgers RW, Gamble JF, Loh KK, Shullenberger CC. Adriamycin, bleomycin, DIC, CCNU, and prednisone (ABDIC) chemotherapy in MOPP-resistant Hodgkin's disease. Cancer. 1980 Dec 1;46(11):2349-55. link to original article PubMed
    1. Update: Tannir N, Hagemeister F, Velasquez W, Cabanillas F. Long-term follow-up with ABDIC salvage chemotherapy of MOPP-resistant Hodgkin's disease. J Clin Oncol. 1983 Jul;1(7):432-9. link to original article PubMed

ABVD

back to top

ABVD: Adriamycin (Doxorubicin), Bleomycin, Vinblastine, Dacarbazine

Regimen

Study Evidence
Krikorian et al. 1978 Phase II
Santoro et al. 1979 Phase II
Harker et al. 1984 Non-randomized

This is for historical interest only; ABVD is no longer used in the salvage setting.

References

  1. Krikorian JG, Portlock CS, Rosenberg SA. Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy. Cancer. 1978 Jun;41(6):2107-11. link to original article PubMed
  2. Santoro A, Bonadonna G. Prolonged disease-free survival in MOPP-resistant Hodgkin's disease after treatment with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). Cancer Chemother Pharmacol. 1979;2(2):101-5. PubMed
  3. Santoro A, Bonfante V, Bonadonna G. Salvage chemotherapy with ABVD in MOPP-resistant Hodgkin's disease. Ann Intern Med. 1982 Feb;96(2):139-43. link to original article PubMed
  4. Harker WG, Kushlan P, Rosenberg SA. Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe. Ann Intern Med. 1984 Oct;101(4):440-6. link to original article PubMed

B-CAVe

back to top

B-CAVe: Bleomycin, CCNU (Lomustine), Adriamycin (Doxorubicin), Vinblastine

Regimen

Study Evidence
Porzig et al. 1978 Non-randomized
Harker et al. 1984 Non-randomized

References

  1. Porzig KJ, Portlock CS, Robertson A, Rosenberg SA. Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure. Cancer. 1978 May;41(5):1670-5. link to original article PubMed
  2. Harker WG, Kushlan P, Rosenberg SA. Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe. Ann Intern Med. 1984 Oct;101(4):440-6. link to original article PubMed

BVCPP

back to top

BVCPP: BCNU (Carmustine), Vinblastine, Cyclophosphamide, Procarbazine, Prednisone

Regimen

Study Evidence
Durant et al. 1978 Non-randomized

Patients who achieved CR were randomized to no additional therapy, 6 monthly cycles of MOPP or 6 additional monthly cycles of BVCPP.

References

  1. Durant JR, Gams RA, Velez-Garcia E, Bartolucci A, Wirtschafter D, Dorfman R. BCNU, velban, cyclophosphamide, procarbazine, and prednisone (BVCPP) in advanced Hodgkin's disease. Cancer. 1978 Nov;42(5):2101-10. link to original article PubMed

CEP

back to top

CEP: CCNU (Lomustine), Etoposide, Prednimustine

Regimen

Study Evidence
Santoro et al. 1986 Non-randomized

References

  1. Santoro A, Viviani S, Valagussa P, Bonfante V, Bonadonna G. CCNU, etoposide, and prednimustine (CEP) in refractory Hodgkin's disease. Semin Oncol. 1986 Mar;13(1 Suppl 1):23-6. PubMed

SCAB

back to top

SCAB: Streptozocin, CCNU (Lomustine), Adriamycin (Doxorubicin), Bleomycin

Regimen

Study Evidence
Levi et al. 1977 Non-randomized, <20 patients

References

  1. Levi JA, Wiernik PH, Diggs CH. Combination chemotherapy of advanced previously treated Hodgkin's disease with streptozotocin, CCNU, adriamycin and bleomycin. Med Pediatr Oncol. 1977;3(1):33-40. PubMed
Retrieved from "https://hemonc.org/w/index.php?title=Classical_Hodgkin_lymphoma_-_historical&oldid=9868"