Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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==Definition of thrombocytopenia== | ==Definition of thrombocytopenia== | ||
| − | Platelet count less than 150 | + | Platelet count less than 150 x 10<sup>9</sup>/L or less than the lower limit of normal as defined by a local laboratory. |
==Evaluation== | ==Evaluation== | ||
Latest revision as of 16:23, 20 June 2024
- We have moved How I Treat articles to a dedicated page.
Definition of thrombocytopenia
Platelet count less than 150 x 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP