Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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| + | *''We have moved [[How I Treat]] articles to a dedicated page.'' | ||
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==Definition of thrombocytopenia== | ==Definition of thrombocytopenia== | ||
| − | Platelet count less than 150 | + | Platelet count less than 150 x 10<sup>9</sup>/L or less than the lower limit of normal as defined by a local laboratory. |
==Evaluation== | ==Evaluation== | ||
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*Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | *Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | ||
*[[Peripheral smear findings|Peripheral smear]], platelet clumps | *[[Peripheral smear findings|Peripheral smear]], platelet clumps | ||
| − | *Clinical history (bleeding, temporality, recent infections), [[ | + | *Clinical history (bleeding, temporality, recent infections), [[Acquired thrombotic thrombocytopenic purpura|TTP]]/[[Atypical hemolytic uremic syndrome|aHUS]] |
*Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | *Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | ||
*Lifestyle factors (e.g. alcohol) | *Lifestyle factors (e.g. alcohol) | ||
| Line 35: | Line 30: | ||
*[[Heparin-induced thrombocytopenia (HIT)]] | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
*[[Thrombocytopenia in liver disease]] | *[[Thrombocytopenia in liver disease]] | ||
| − | *[[ | + | *[[Acquired thrombotic thrombocytopenic purpura]] |
[[Category:Hematology reference pages]] | [[Category:Hematology reference pages]] | ||
Latest revision as of 16:23, 20 June 2024
- We have moved How I Treat articles to a dedicated page.
Definition of thrombocytopenia
Platelet count less than 150 x 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP