Difference between revisions of "Aplastic anemia"
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| − | ===Regimen | + | ===Regimen {{#subobject:ca8fc4|Variant=1}}=== |
| − | <span | + | {| border="1" style="text-align:center;" !align="left" |
| + | |'''Study''' | ||
| + | |[[Levels_of_Evidence#Evidence|'''Evidence''']] | ||
| + | |- | ||
| + | |[http://www.nejm.org/doi/full/10.1056/NEJMoa1200931 Olnes et al. 2012] | ||
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style="background:#EEEE00; | style="background:#EEEE00; | ||
padding:3px 6px 3px 6px; | padding:3px 6px 3px 6px; | ||
border-color:black; | border-color:black; | ||
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| − | border-style:solid;"> | + | border-style:solid;">Phase II</span> |
| + | |- | ||
| + | |} | ||
*[[Eltrombopag (Promacta)]] 50 mg PO once per day, increased by 25 mg every 2 weeks until platelet count > 20,000 per µL or maximum of 150 mg daily dose | *[[Eltrombopag (Promacta)]] 50 mg PO once per day, increased by 25 mg every 2 weeks until platelet count > 20,000 per µL or maximum of 150 mg daily dose | ||
===References=== | ===References=== | ||
| − | # Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012 Jul 5;367(1):11-9. Erratum in: N Engl J Med. 2012 Jul 19;367(3):284. [http://www.nejm.org/doi/full/10.1056/NEJMoa1200931 | + | # Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012 Jul 5;367(1):11-9. Erratum in: N Engl J Med. 2012 Jul 19;367(3):284. [http://www.nejm.org/doi/full/10.1056/NEJMoa1200931 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/22762314 PubMed] |
## '''Update:''' Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014 Mar 20;123(12):1818-25. Epub 2013 Dec 17. [http://bloodjournal.hematologylibrary.org/content/123/12/1818.full link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/24345753 PubMed] | ## '''Update:''' Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014 Mar 20;123(12):1818-25. Epub 2013 Dec 17. [http://bloodjournal.hematologylibrary.org/content/123/12/1818.full link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/24345753 PubMed] | ||
Revision as of 15:22, 31 August 2015
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9 regimens on this page
12 variants on this page
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Initial therapy
Relapsed/Refractory
Eltrombopag (Promacta)
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Regimen
| Study | Evidence |
| Olnes et al. 2012 | Phase II |
- Eltrombopag (Promacta) 50 mg PO once per day, increased by 25 mg every 2 weeks until platelet count > 20,000 per µL or maximum of 150 mg daily dose
References
- Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012 Jul 5;367(1):11-9. Erratum in: N Engl J Med. 2012 Jul 19;367(3):284. link to original article contains verified protocol PubMed
- Update: Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014 Mar 20;123(12):1818-25. Epub 2013 Dec 17. link to original article contains verified protocol PubMed