Difference between revisions of "Craniopharyngioma"

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'''Given the rapid change in evidence in many areas of hematology/oncology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.'''
 
==[https://www.nccn.org/ NCCN]==
 
==[https://www.nccn.org/ NCCN]==
 
*''NCCN does not have guidelines at this granular level; please go to the [[:Category:CNS cancers|Central Nervous System Cancers category page]].''
 
*''NCCN does not have guidelines at this granular level; please go to the [[:Category:CNS cancers|Central Nervous System Cancers category page]].''

Revision as of 19:15, 17 October 2023

Section editor
SeemaNagpal.jpg
Seema Nagpal, MD
Stanford University
Palo Alto, CA, USA

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Guidelines

Given the rapid change in evidence in many areas of hematology/oncology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

NCCN

All lines of therapy

Cobimetinib & Vemurafenib

Regimen

Study Dates of enrollment Evidence
Brastianos et al. 2023 (Alliance A071601) NR in abstract Phase 2

Eligibility criteria

  • Histology: Papillary

Biomarker eligibility criteria

  • BRAF mutation

Targeted therapy

28-day cycles

References

  1. Alliance A071601: Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA, Reardon DA, Cohen AL, De La Fuente MI, Lesser GJ, Campian J, Agarwalla PK, Kumthekar P, Mann B, Vora S, Knopp M, Iafrate AJ, Curry WT Jr, Cahill DP, Shih HA, Brown PD, Santagata S, Barker FG 2nd, Galanis E. BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. N Engl J Med. 2023 Jul 13;389(2):118-126. link to original article PubMed NCT03224767