Difference between revisions of "Fotemustine (Muphoran)"
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From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=38865 NCI Drug Dictionary]: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. | From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=38865 NCI Drug Dictionary]: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. | ||
− | == | + | ==Diseases for which it is used== |
+ | *[[Diffuse large B-cell lymphoma]] | ||
+ | *[[Classical Hodgkin lymphoma]] | ||
+ | *[[Melanoma]] | ||
+ | **[[CNS melanoma]] | ||
+ | **[[Uveal melanoma]] | ||
− | == | + | ==History of changes in EMA indication== |
− | + | *1989-04-14: EURD | |
+ | ==Also known as== | ||
+ | *'''Brand names:''' Muphoran, Mustophoran | ||
− | + | [[Category:Drugs]] | |
− | |||
− | |||
− | |||
− | [[Category: | ||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
− | [[Category: | + | [[Category:Nitrosoureas]] |
− | [[Category:Hodgkin lymphoma medications]] | + | [[Category:Diffuse large B-cell lymphoma medications]] |
− | [[Category: | + | [[Category:Classical Hodgkin lymphoma medications]] |
+ | [[Category:Melanoma medications]] | ||
+ | [[Category:Uveal melanoma medications]] | ||
− | [[Category: | + | [[Category:EMA approved in 1989]] |
Revision as of 11:56, 11 June 2023
Mechanism of action
From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
Diseases for which it is used
History of changes in EMA indication
- 1989-04-14: EURD
Also known as
- Brand names: Muphoran, Mustophoran