Difference between revisions of "Dacarbazine (DTIC)"

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==General information==
 
==General information==
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Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[https://labeling.pfizer.com/ShowLabeling.aspx?id=5938 Dacarbazine (DTIC) package insert]</ref><ref>[[:File:Dacarbazine.pdf | Dacarbazine (DTIC) package insert (locally hosted backup)]]</ref>
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Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[https://labeling.pfizer.com/ShowLabeling.aspx?id=5938 Dacarbazine (DTIC) package insert]</ref><ref>[[:File:Dacarbazine.pdf | Dacarbazine (DTIC) package insert (locally hosted backup)]]</ref>
 
<br>Route: IV
 
<br>Route: IV
 
<br>Extravasation: [[irritant]]
 
<br>Extravasation: [[irritant]]

Revision as of 01:44, 1 June 2023

General information

Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.[1][2]
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is established (work in progress)

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 1975-05-27: Initial FDA approval
  • Uncertain date: indicated in the treatment of metastatic malignant melanoma. (No supporting studies are cited)
  • Uncertain date: Indicated for Hodgkin's disease as a second-line therapy when used in combination with other effective agents. (No supporting studies are cited)

Also known as

  • Generic names: dacarbazin, DTIC, imidazole carboxamide
  • Brand names: Bazipar, Cedcozine, Dacarba, Dacarex, Dacin, Dacmed, Darbazine, Dazine, Decarb, Oncodac, Zydac

References

  1. ↑ 1.0 1.1 Dacarbazine (DTIC) package insert
  2. ↑ Dacarbazine (DTIC) package insert (locally hosted backup)
  3. ↑ Dacarbazine (DTIC) patient drug information (Chemocare)
  4. ↑ Dacarbazine (DTIC) patient drug information (UpToDate)
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