Difference between revisions of "Nedaplatin (Aqupla)"
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Line 9: | Line 9: | ||
*[[Nasopharyngeal carcinoma]] | *[[Nasopharyngeal carcinoma]] | ||
*[[Non-small cell lung cancer, squamous]] | *[[Non-small cell lung cancer, squamous]] | ||
+ | *[[Non-small cell lung cancer, EGFR-mutated]] | ||
==Also known as== | ==Also known as== | ||
*'''Code name:''' 254-S | *'''Code name:''' 254-S | ||
*'''Generic name:''' nedaplat | *'''Generic name:''' nedaplat | ||
*'''Brand name:''' Aqupla, Jiebaishu | *'''Brand name:''' Aqupla, Jiebaishu | ||
− | + | ==History of changes in NMPA indication== | |
+ | *2005: Initial approval | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Line 24: | Line 26: | ||
[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
[[Category:Nasopharyngeal carcinoma medications]] | [[Category:Nasopharyngeal carcinoma medications]] | ||
+ | [[[[Category:Non-small cell lung cancer medications]] | ||
[[Category:Non-small cell lung cancer, squamous medications]] | [[Category:Non-small cell lung cancer, squamous medications]] | ||
[[Category:PMDA approved drugs]] | [[Category:PMDA approved drugs]] | ||
+ | [[Category:NMPA approved in 2005]] |
Revision as of 14:13, 11 February 2023
General information
Class/mechanism: A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. [1]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
- Cervical cancer
- Nasopharyngeal carcinoma
- Non-small cell lung cancer, squamous
- Non-small cell lung cancer, EGFR-mutated
Also known as
- Code name: 254-S
- Generic name: nedaplat
- Brand name: Aqupla, Jiebaishu
History of changes in NMPA indication
- 2005: Initial approval
References
[[