Difference between revisions of "Neuroblastoma - historical"

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=High Risk=
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==COG ANBL0532==
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===Consolidation,===
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====Chemotherapy,====
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'''Day 0 Corresponds to PBSC Infusion'''
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*[[Melphalan (Alkeran)]] by the following criteria:
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**Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 2.3 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
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**Patients with GFR ≥ 100 mL/min and > 12 kg: 70 mg/m<sup>2</sup> IV over 15 to 30 minutes once daily on days -7, -6, -5
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 60 mg/m<sup>2</sup> IV over 15 to 30 minutes once daily on days -7, -6, -5
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 2 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
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*[[Etoposide (Vepesid)]] by the following criteria:
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**Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 11.3 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR ≥ 100 mL/min and > 12 kg: 338 mg/m<sup>2</sup> IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 200 mg/m<sup>2</sup> IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 6.7 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
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*[[Carboplatin (Paraplatin)]] by the following criteria:
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**Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 14.2 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR ≥ 100 mL/min and > 12 kg: 425 mg/m<sup>2</sup> IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose = 300 mg/m<sup>2</sup>) IV over 24 hours once daily on days -7, -6, -5, -4
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**Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose of 10 mg/kg) IV over 24 hours once daily on days -7, -6, -5, -4
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'''36 Day Cycle'''
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====Supportive Therapy,====
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*[[Filgrastim (Neupogen)]] 5 μg/kg SubQ or IV once daily on day 0 and continuing until ANC > 2000 μL for 3 consecutive days
 +
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'''36 Day Cycle'''

Revision as of 21:05, 14 November 2022

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Section editor transclusions

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main neuroblastoma page for current regimens.

2 regimens on this page
2 variants on this page


High Risk

COG ANBL0532

Consolidation,

Chemotherapy,

Day 0 Corresponds to PBSC Infusion

  • Melphalan (Alkeran) by the following criteria:
    • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 2.3 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
    • Patients with GFR ≥ 100 mL/min and > 12 kg: 70 mg/m2 IV over 15 to 30 minutes once daily on days -7, -6, -5
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 60 mg/m2 IV over 15 to 30 minutes once daily on days -7, -6, -5
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 2 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
  • Etoposide (Vepesid) by the following criteria:
    • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 11.3 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR ≥ 100 mL/min and > 12 kg: 338 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 200 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 6.7 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
  • Carboplatin (Paraplatin) by the following criteria:
    • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 14.2 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR ≥ 100 mL/min and > 12 kg: 425 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose = 300 mg/m2) IV over 24 hours once daily on days -7, -6, -5, -4
    • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose of 10 mg/kg) IV over 24 hours once daily on days -7, -6, -5, -4

36 Day Cycle

Supportive Therapy,

  • Filgrastim (Neupogen) 5 μg/kg SubQ or IV once daily on day 0 and continuing until ANC > 2000 μL for 3 consecutive days

36 Day Cycle

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