Difference between revisions of "Fotemustine (Muphoran)"

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search
m
m
Line 3: Line 3:
  
 
==Diseases for which it is used==
 
==Diseases for which it is used==
*[[CNS melanoma]]
+
*[[Diffuse large B-cell lymphoma]]
 +
*[[Hodgkin lymphoma]]
 
*[[Melanoma]]
 
*[[Melanoma]]
*[[Uveal melanoma]]
+
**[[CNS melanoma]]
 +
**[[Uveal melanoma]]
  
 
==Also known as==
 
==Also known as==
Line 14: Line 16:
 
[[Category:Nitrosoureas]]
 
[[Category:Nitrosoureas]]
  
 +
[[Category:Diffuse large B-cell lymphoma medications]]
 +
[[Category:Hodgkin lymphoma medications]]
 
[[Category:Melanoma medications]]
 
[[Category:Melanoma medications]]
 
[[Category:Uveal melanoma medications]]
 
[[Category:Uveal melanoma medications]]
  
 
[[Category:EMA approved drugs]]
 
[[Category:EMA approved drugs]]

Revision as of 01:41, 14 May 2022

Mechanism of action

From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

Diseases for which it is used

Also known as

  • Brand names: Muphoran, Mustophoran