Difference between revisions of "Epirubicin (Ellence)"

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Also known as Epirubicin Ebewe.
 
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==General information==
 
==General information==
 
Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis.  Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[[Media:Epirubicin.pdf | Epirubicin (Ellence) package insert (locally hosted backup)]]</ref>
 
Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis.  Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[[Media:Epirubicin.pdf | Epirubicin (Ellence) package insert (locally hosted backup)]]</ref>
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*Brief patient counseling information can be found on [http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf#page=15 pages 15-16 of the Epirubicin (Ellence) package insert]<ref name="insert"></ref>
 
*Brief patient counseling information can be found on [http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf#page=15 pages 15-16 of the Epirubicin (Ellence) package insert]<ref name="insert"></ref>
 
*[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 9/15/1999: Initial FDA approval "as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary [[Breast cancer | breast cancer]]."
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==Also known as==
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{| border="1" style="text-align:center;"
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!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
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|-
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|Alrubicin
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|Anthracin
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|Binarin
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|Bioepicyna
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|Crisabon
 +
|-
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|E.P.R Elvetium
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|Ellence
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|EPI
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|EPI Cell
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|Epidoxo
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|-
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|Epifil
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|Epilem
 +
|Epirubicin
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|Epirubicina Microsules
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|Epirubicine
 +
|-
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|Epirubicin Ebewe
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|Epirubicine HCl PCH
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|Epirubicin Hexal
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|Epirubicin Hydrochloride
 +
|Epizin
 +
|-
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|Epricin
 +
|Eracin
 +
|Famorubicin
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|Farmorubicin
 +
|Farmorubicin-RTU
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|-
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|Farmorubicina
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|Farmorubicina CS
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|Farmorubicina PFS / RTU
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|Farmorubicin CS
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|Farmorubicin DR
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|-
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|Farmorubicine
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|Farmorubicine R.T.U.
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|Farmorubicine RTU
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|Farmorubicin HL
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|Farmorubicin PFS
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|-
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|Farmorubicin RD
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|Farmorubicin Solution
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|Pharmorubicin CS
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|Riboepi
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|Rubifarm
 +
|-
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|Trav Epirubicin
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|Vero Epirubicin
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|}
  
 
==References==
 
==References==
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[[Category:Topoisomerase inhibitors]]
 
[[Category:Topoisomerase inhibitors]]
 
[[Category:DNA synthesis inhibitors]]
 
[[Category:DNA synthesis inhibitors]]
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[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
 
[[Category:Breast cancer medications]]
 
[[Category:Breast cancer medications]]
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[[Category:Gastric cancer medications]]
 
[[Category:Gastric cancer medications]]
 
[[Category:Hepatobiliary cancer medications]]
 
[[Category:Hepatobiliary cancer medications]]
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[[Category:Sarcoma medications]]
 
[[Category:Testicular cancer medications]]
 
[[Category:Testicular cancer medications]]
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[[Category:Drugs FDA approved in 1999]]

Revision as of 01:35, 30 October 2014

General information

Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.[1][2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 9/15/1999: Initial FDA approval "as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer."

Also known as

Synonyms
Alrubicin Anthracin Binarin Bioepicyna Crisabon
E.P.R Elvetium Ellence EPI EPI Cell Epidoxo
Epifil Epilem Epirubicin Epirubicina Microsules Epirubicine
Epirubicin Ebewe Epirubicine HCl PCH Epirubicin Hexal Epirubicin Hydrochloride Epizin
Epricin Eracin Famorubicin Farmorubicin Farmorubicin-RTU
Farmorubicina Farmorubicina CS Farmorubicina PFS / RTU Farmorubicin CS Farmorubicin DR
Farmorubicine Farmorubicine R.T.U. Farmorubicine RTU Farmorubicin HL Farmorubicin PFS
Farmorubicin RD Farmorubicin Solution Pharmorubicin CS Riboepi Rubifarm
Trav Epirubicin Vero Epirubicin

References

  1. ↑ 1.0 1.1 1.2 Epirubicin (Ellence) package insert
  2. ↑ Epirubicin (Ellence) package insert (locally hosted backup)
  3. ↑ Epirubicin (Ellence) patient drug information (Chemocare)
  4. ↑ Epirubicin (Ellence) patient drug information (UpToDate)
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