Difference between revisions of "Fotemustine (Muphoran)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
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*[[Melanoma]] | *[[Melanoma]] | ||
*[[Uveal melanoma]] | *[[Uveal melanoma]] | ||
Revision as of 13:44, 12 February 2020
Mechanism of action
From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
Diseases for which it is used
Also known as
- Brand names: Muphoran, Mustophoran