Difference between revisions of "Bone sarcoma"
Jump to navigation
Jump to search
m |
m |
||
| Line 1: | Line 1: | ||
| − | + | {| class="wikitable" style="text-align:center; width:50%;" | |
!colspan="2" align="center" style="color:white; font-size:125%; background-color:#08519c"|'''Section editor''' | !colspan="2" align="center" style="color:white; font-size:125%; background-color:#08519c"|'''Section editor''' | ||
|- | |- | ||
| − | |style="background-color:#F0F0F0"|[[File: | + | |style="background-color:#F0F0F0"|[[File:Elizabethdavis2.jpg|frameless|upright=0.3|center]] |
| − | |<big>[[User: | + | |<big>[[User:Elizabethdavis|Elizabeth J. Davis, MD]]<br>Nashville, TN</big><br>[[File:Social-twitter-icon.png|frameless|upright=0.1]][https://twitter.com/ejdavis25 ejdavis25] |
|- | |- | ||
| − | |} | + | |} |
{| class="wikitable" style="float:right; margin-right: 5px;" | {| class="wikitable" style="float:right; margin-right: 5px;" | ||
|- | |- | ||
Revision as of 19:43, 2 October 2019
| Section editor | |
|---|---|
 |
Elizabeth J. Davis, MD Nashville, TN  ejdavis25
|
0 regimens on this page
0 variants on this page
|
Note: this page is for subtype-nonspecific bone sarcoma regimens, and some subtypes with very few subtype-specific regimens. Please see the category page for links to other sarcoma types or use one of these links:
Guidelines
ESMO
NCCN
Chondrosarcoma, all lines of therapy
- No standard chemotherapy for grades 1 to 3 conventional chondrosarcoma
- Mesenchymal chondrosarcoma has been treated with Ewing's sarcoma regimens
- Dedifferentiated chondrosarcoma has been treated with osteosarcoma regimens
Giant-cell tumor of bone, all lines of therapy
Denosumab monotherapy
| back to top |
Regimen
| Study | Evidence |
|---|---|
| Thomas et. al 2010 | Phase II |
Chemotherapy
- Denosumab (Xgeva) as follows:
- Cycle 1: 120 mg SC once per day on days 1, 8, 15
- Cycle 2 onwards: 120 mg SC once on day 1
Supportive medications
- Calcium 500 mg PO once per day
- Vitamin D 400 IU PO once per day
28-day cycles
References
- Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed
Malignant fibrous histiocytoma (MFH) of bone, all lines of therapy
- Malignant fibrous histiocytoma (MFH) of bone has been treated with osteosarcoma regimens