Difference between revisions of "Temozolomide (Temodar)"
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*[[Soft tissue sarcoma]] | *[[Soft tissue sarcoma]] | ||
*[[Small cell lung cancer]] | *[[Small cell lung cancer]] | ||
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==Patient drug information== | ==Patient drug information== | ||
*[https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf Temozolomide (Temodar) package insert]<ref name="insert"></ref> | *[https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf Temozolomide (Temodar) package insert]<ref name="insert"></ref> | ||
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[[Category:Soft tissue sarcoma medications]] | [[Category:Soft tissue sarcoma medications]] | ||
[[Category:Small cell lung cancer medications]] | [[Category:Small cell lung cancer medications]] | ||
| + | [[Category:Uveal melanoma medications]] | ||
[[Category:FDA approved in 1999]] | [[Category:FDA approved in 1999]] | ||
Revision as of 02:08, 5 August 2019
General information
Class/mechanism: Alkylator. Temozolomide is converted in vivo to the reactive compound 5-(3-methyltriazen-
1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.[1][2]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Anaplastic glioma
- CNS lymphoma
- Ewing sarcoma
- Glioblastoma
- Low-grade glioma
- Melanoma
- Myelodysplastic syndrome
- Neuroblastoma
- Neuroendocrine tumor
- Pancreatic NET
- Soft tissue sarcoma
- Small cell lung cancer
- Uveal melanoma
Patient drug information
- Temozolomide (Temodar) package insert[1]
- Temozolomide (Temodar) patient drug information (Chemocare)[3]
- Temozolomide (Temodar) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 8/11/1999: Initial FDA approval
Also known as
- Generic name: TMZ
- Brand names: Gliotem, Temcad, Temizole, Temodal, Temodar, Temonat, Temoside, Temoz, Temzol
References
- Drugs
- Intravenous medications
- Oral medications
- Triazenes
- Alkylating agents
- Acute myeloid leukemia medications
- Anaplastic glioma medications
- CNS lymphoma medications
- Ewing sarcoma medications
- Glioblastoma medications
- Low-grade glioma medications
- Melanoma medications
- Myelodysplastic syndrome medications
- Neuroblastoma medications
- Neuroendocrine tumor medications
- Pancreatic NET medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- Uveal melanoma medications
- FDA approved in 1999