Difference between revisions of "Arsenic trioxide (Trisenox)"
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==General information== | ==General information== | ||
− | Class/mechanism: Causes damage or degradation of PML-RAR alpha fusion protein, causes apoptosis-type changes in NB4 human promyelocytic leukemia cells in vitro.<ref name="insert">[ | + | Class/mechanism: Causes damage or degradation of PML-RAR alpha fusion protein, causes apoptosis-type changes in NB4 human promyelocytic leukemia cells in vitro.<ref name="insert">[https://www.trisenox.com/globalassets/trisenoxhcp/trisenox-prescribing-information.pdf Arsenic trioxide (Trisenox) package insert]</ref><ref>[[Media:Arsenictrioxide.pdf | Arsenic trioxide (Trisenox) package insert (locally hosted backup)]]</ref><ref>[https://www.trisenox.com/ Trisenox manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
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==Patient drug information== | ==Patient drug information== | ||
+ | *[https://www.trisenox.com/globalassets/trisenoxhcp/trisenox-prescribing-information.pdf Arsenic trioxide (Trisenox) package insert]<ref name="insert"></ref> | ||
*[http://chemocare.com/chemotherapy/drug-info/arsenic-trioxide.aspx Arsenic trioxide (Trisenox) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/arsenic-trioxide.aspx Arsenic trioxide (Trisenox) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/arsenic-trioxide.aspx Arsenic trioxide (Trisenox) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/arsenic-trioxide.aspx Arsenic trioxide (Trisenox) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Arsenic trioxide (Trisenox) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Arsenic trioxide (Trisenox) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Arsenic trioxide (Trisenox) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/arsenic-trioxide-patient-drug-information Arsenic trioxide (Trisenox) patient drug information (UpToDate)]</ref> |
Revision as of 16:20, 18 May 2019
General information
Class/mechanism: Causes damage or degradation of PML-RAR alpha fusion protein, causes apoptosis-type changes in NB4 human promyelocytic leukemia cells in vitro.[1][2][3]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Arsenic trioxide (Trisenox) package insert[1]
- Arsenic trioxide (Trisenox) patient drug information (Chemocare)[4]
- Arsenic trioxide (Trisenox) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 9/25/2000: Initial FDA approval for "induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression."
Also known as
- Brand names: Arsenol, Arsenox, Leusenox, Trisenox