Arsenic trioxide (Trisenox)
Class/mechanism: Causes damage or degradation of PML-RAR alpha fusion protein, causes apoptosis-type changes in NB4 human promyelocytic leukemia cells in vitro.
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Diseases for which it is used
Patient drug information
- Arsenic trioxide (Trisenox) patient drug information (Chemocare)
- Arsenic trioxide (Trisenox) patient drug information (UpToDate)
History of changes in FDA indication
- 9/25/2000: Initial FDA approval for "induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy, and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression."
Also known as
- Brand names: Arsenol, Arsenox, Leusenox, Trisenox