Revision as of 21:32, 24 January 2019

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	Andrew J. Cowan, MD Seattle, WA LinkedIn

POEMS: Peripheral neuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes

1 regimens on this page 1 variants on this page

Guidelines

EMN

2018: Gavriatopoulou et al. European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias PubMed

All lines of therapy

RD

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RD: Revlimid (Lenalidomide) & Dexamethasone

Regimen

Study	Evidence
Nozza et al. 2017	Phase II, <20 pts

Chemotherapy

Lenalidomide (Revlimid) 25 mg PO once per day on days 1 to 21
Dexamethasone (Decadron) 40 mg PO once per week

Supportive medications

Aspirin 100 mg PO once per day
- LMWH in "intolerant" patients
Cotrimoxazole 800 mg PO twice per day two days per week

Monthly cycles, continued until progression or excess toxicity

References

Nozza A, Terenghi F, Gallia F, Adami F, Briani C, Merlini G, Giordano L, Santoro A, Nobile-Orazio E. Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. Br J Haematol. 2017 Dec;179(5):748-755. Epub 2017 Oct 19. link to original article contains verified protocol PubMed

@@ Line 45: / Line 45: @@
 *[[Aspirin]] 100 mg PO once per day
 **[[:Category:Low_molecular_weight_heparins|LMWH]] in "intolerant" patients
-*[[Trimethoprim/Sulfamethoxazole_(Bactrim_DS)|Cotrimoxazole]] 800 mg PO BID two days per week
+*[[Trimethoprim/Sulfamethoxazole_(Bactrim_DS)|Cotrimoxazole]] 800 mg PO twice per day two days per week
 '''Monthly cycles, continued until progression or excess toxicity'''

Difference between revisions of "POEMS syndrome"