Pegaspargase (Oncaspar)

General information

Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase. The Oncaspar formulation involves L-asparaginase (L-asparagine amidohydrolase) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life and reducing the risk of hypersensitivity reactions in patients who have history of hypersensitivity to Asparaginase (Elspar).
Route: IV, IM
Extravasation: neutral

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• B-cell acute lymphoblastic leukemia
• Extranodal NK/T-cell lymphoma, nasal type
• NK/T-cell lymphoma
• T-cell acute lymphoblastic leukemia

Patient drug information

• Pegaspargase (Oncaspar) patient drug information (Chemocare)
• Pegaspargase (Oncaspar) patient drug information (UpToDate)

History of changes in FDA indication

• 2/1/1994: Initial FDA approval
• 7/24/2006: FDA approved for the first-line treatment of patients with acute lymphoblastic leukemia.

Also known as

• Generic names: PEG-L-asparaginase, peg-asparginase, pegasparaginase
• Brand name: Oncaspar