Difference between revisions of "Example orders for CapeOx (XELOX) in colon cancer"
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| + | Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature. | ||
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Revision as of 06:41, 17 June 2013
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
CapeOx (XELOX)
CapeOX: Capecitabine, OXaliplatin
XELOX: XELoda, OXaliplatin
Original references may be found at CapeOx (XELOX) (adjuvant) & CapeOx (XELOX) (metastatic)
Example regimen #1
- Capecitabine (Xeloda) 1000 mg/m2 PO BID on days 1-14
- Oxaliplatin (Eloxatin) 130 mg/m2 IV over 2 hours on day 1
- Mix in 500 mL D5W, and only infuse through D5W line.
21-day cycles x 8 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity
Supportive medications:
- Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy
- Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy
- Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start prior to oxaliplatin to decrease likelihood of neuropathy
- Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start after oxaliplatin infusion is complete to decrease likelihood of neuropathy
Hydration:
- 500 ml D5W at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml D5W.
Monitoring:
- Hold if ANC <1000 or platelets <100 and notify physician.
Comments:
- My institution uses the schedule described by Haller, et al. 2011.