Difference between revisions of "Docetaxel (Taxotere)"
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==General information== | ==General information== | ||
Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.<ref name="insert">[http://products.sanofi.us/taxotere/taxotere.pdf Docetaxel (Taxotere) package insert]</ref><ref>[[Media:Docetaxel.pdf | Docetaxel (Taxotere) package insert (locally hosted backup)]]</ref> | Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.<ref name="insert">[http://products.sanofi.us/taxotere/taxotere.pdf Docetaxel (Taxotere) package insert]</ref><ref>[[Media:Docetaxel.pdf | Docetaxel (Taxotere) package insert (locally hosted backup)]]</ref> | ||
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*[[Cervical cancer]] | *[[Cervical cancer]] | ||
*[[Esophageal cancer]] | *[[Esophageal cancer]] | ||
| + | *[[Head and neck cancer]] | ||
| + | *[[Melanoma]] | ||
*[[Non-small cell lung cancer]] | *[[Non-small cell lung cancer]] | ||
*[[Ovarian cancer]] | *[[Ovarian cancer]] | ||
*[[Pancreatic cancer]] | *[[Pancreatic cancer]] | ||
*[[Prostate cancer]] | *[[Prostate cancer]] | ||
| + | *[[Sarcoma]] | ||
| + | *[[Small cell lung cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
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*[http://products.sanofi.us/taxotere/taxotere.pdf#page=16 Docetaxel (Taxotere) package insert pages 16-17]<ref name="insert"></ref> | *[http://products.sanofi.us/taxotere/taxotere.pdf#page=16 Docetaxel (Taxotere) package insert pages 16-17]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | Asodocel, Docetax, Docetaxel Comp, Docetaxel Delta Farma, Docetaxel Microsules, Docetaxel Sandoz, Docetere, Dolectran, Doxel, Doxetal, Oncodocel, Plustaxano, N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol, Neocel, NSC 628503, RP 56976, Taxotere Aventis, Taxotere Chugai, Texot, Trixotene. | ||
==References== | ==References== | ||
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[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
[[Category:Vesicant chemotherapy]] | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:Microtubule inhibitors]] | ||
[[Category:Taxanes]] | [[Category:Taxanes]] | ||
[[Category:Bone cancer medications]] | [[Category:Bone cancer medications]] | ||
Revision as of 15:39, 14 June 2013
General information
Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Bone cancer
- Breast cancer
- Cancer of unknown primary
- Cervical cancer
- Esophageal cancer
- Head and neck cancer
- Melanoma
- Non-small cell lung cancer
- Ovarian cancer
- Pancreatic cancer
- Prostate cancer
- Sarcoma
- Small cell lung cancer
Patient drug information
- Docetaxel (Taxotere) patient drug information (Chemocare)[3]
- Docetaxel (Taxotere) package insert pages 16-17[1]
- Docetaxel (Taxotere) patient drug information (UpToDate)[4]
Also known as
Asodocel, Docetax, Docetaxel Comp, Docetaxel Delta Farma, Docetaxel Microsules, Docetaxel Sandoz, Docetere, Dolectran, Doxel, Doxetal, Oncodocel, Plustaxano, N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol, Neocel, NSC 628503, RP 56976, Taxotere Aventis, Taxotere Chugai, Texot, Trixotene.
References
- Drug index
- Chemotherapy
- Irritant chemotherapy
- Vesicant chemotherapy
- Microtubule inhibitors
- Taxanes
- Bone cancer medications
- Breast cancer medications
- Cancer of unknown primary medications
- Cervical cancer medications
- Esophageal cancer medications
- Non-small cell lung cancer medications
- Ovarian cancer medications
- Pancreatic cancer medications
- Prostate cancer medications