Difference between revisions of "Fludarabine (Fludara)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.<ref name="insert">[http://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4067b1_15_fludarabine%20label.pdf Fludarabine (Fludara) package insert]</ref><ref>[ | + | Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.<ref name="insert">[http://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4067b1_15_fludarabine%20label.pdf Fludarabine (Fludara) package insert]</ref><ref>[[Media:Fludarabine.pdf | Fludarabine (Fludara) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute myeloid leukemia]] | ||
| + | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
| + | *[[Follicular lymphoma]] | ||
| + | *[[Marginal zone lymphoma]] | ||
| + | *[[Transplant conditioning regimens]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]</ref> | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | * 4/18/1991: Initial FDA approval | + | *4/18/1991: Initial FDA approval |
| + | |||
| + | ==Also known as== | ||
| + | Beneflur, FAMP, Fludarabine Phosphate, Fludara Lyophilisat, Oforta, Trav Fludarabine. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:DNA synthesis inhibitors]] | ||
| + | [[Category:Nucleic acid analogs]] | ||
| + | [[Category:Acute myeloid leukemia medications]] | ||
| + | [[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | ||
| + | [[Category:Follicular lymphoma medications]] | ||
| + | [[Category:Marginal zone lymphoma medications]] | ||
| + | [[Category:Transplant medications]] | ||
Revision as of 15:30, 11 June 2013
General information
Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Follicular lymphoma
- Marginal zone lymphoma
- Transplant conditioning regimens
Patient drug information
- Fludarabine (Fludara) patient drug information (Chemocare)[3]
- Fludarabine (Fludara) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 4/18/1991: Initial FDA approval
Also known as
Beneflur, FAMP, Fludarabine Phosphate, Fludara Lyophilisat, Oforta, Trav Fludarabine.