Difference between revisions of "Fluorouracil (5-FU)"

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m (Text replacement - "manufacturer. Instead" to "manufacturer. Instead")
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*[[Breast cancer]]
 
*[[Breast cancer]]
 
*[[Cervical cancer]]
 
*[[Cervical cancer]]
 +
*[[Cholangiocarcinoma]]
 
*[[Colon cancer]]
 
*[[Colon cancer]]
 
*[[Esophageal cancer]]
 
*[[Esophageal cancer]]
 
*[[Gastric cancer]]
 
*[[Gastric cancer]]
 
*[[Head and neck cancer]]
 
*[[Head and neck cancer]]
−
*[[Hepatobiliary cancer]]
+
*[[Hepatocellular carcinoma]]
 +
*[[Nasopharyngeal carcinoma]]
 
*[[Neuroendocrine tumors]]
 
*[[Neuroendocrine tumors]]
 
*[[Pancreatic cancer]]
 
*[[Pancreatic cancer]]
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*[[Prostate cancer]]
 
*[[Prostate cancer]]
 
*[[Rectal cancer]]
 
*[[Rectal cancer]]
−
*[[Unknown primary]]
+
*[[SCC of unknown primary]]
 +
 
 +
==Diseases for which it was used==
 +
*[[Diffuse large B-cell lymphoma - obsolete|Diffuse large B-cell lymphoma]]
  
 
==Patient drug information==
 
==Patient drug information==
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==Also known as==
 
==Also known as==
 +
*'''Generic names:''' 5 Fluorouracil, 5 FU, 5-fluoracilo, 5-fluorouracilo, 5-fluorouracyl, FU
 +
*'''Brand names:'''
 
{| border="1" style="text-align:center;"
 
{| border="1" style="text-align:center;"
 
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 
|-
 
|-
−
|5 Fluorouracil
 
−
|5 FU
 
−
|5 FU Kyowa Hakko
 
−
|5 FU Meiji
 
−
|5 FU Orca
 
−
|5-fluoracilo
 
−
|5-fluorouracilo
 
−
|5-fluorouracyl-knoll
 
−
|-
 
−
|5-FU Kyowa
 
−
|5-FU Medac
 
 
|Accusite
 
|Accusite
 
|Actino Hermal
 
|Actino Hermal
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|Benton
 
|Benton
 
|Biofur
 
|Biofur
−
|-
 
 
|Carac
 
|Carac
 
|Carebin
 
|Carebin
 +
|-
 
|Carzonal
 
|Carzonal
 
|Cinco-FU
 
|Cinco-FU
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|Effcil
 
|Effcil
 
|Efudex
 
|Efudex
−
|-
 
 
|Efurix
 
|Efurix
 
|Ezadex
 
|Ezadex
 +
|-
 
|Fauldfluor
 
|Fauldfluor
 
|Fivocil
 
|Fivocil
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|Flonida
 
|Flonida
 
|Florac
 
|Florac
−
|-
 
−
|Flourouracil
 
 
|Fluhomer
 
|Fluhomer
 
|Fluolex
 
|Fluolex
 +
|-
 +
|Fluoroplex
 
|Fluor-Uracil
 
|Fluor-Uracil
 
|Fluoro-Uracile ICN
 
|Fluoro-Uracile ICN
 
|Fluoro-Uracil ICN
 
|Fluoro-Uracil ICN
−
|Fluoroplex
 
−
|Fluorouracil
 
−
|-
 
−
|Fluorouracil-GRY
 
−
|Fluorouracil 5 FU
 
−
|Fluorouracil Abic
 
−
|Fluorouracil Bigmar
 
−
|Fluorouracil CO
 
−
|Fluorouracil DBL
 
 
|Fluorouracile
 
|Fluorouracile
−
|Fluorouracile Dakota
 
−
|-
 
−
|Fluorouracil Faulding
 
−
|Fluorouracil Mayne
 
−
|Fluorouracil Mayne Pharma ( BEN )
 
 
|Fluorouracilo
 
|Fluorouracilo
−
|Fluorouracilo Filaxis
 
−
|Fluorouracilo Martian
 
−
|Fluorouracilo Rontag
 
−
|Fluorouracil Pliva
 
−
|-
 
−
|Fluorouracil Roche
 
−
|Fluorouracil Sanofi-Synthelabo
 
−
|Fluorouracil Sodium
 
−
|Fluorouracil Till
 
 
|Fluorourcil
 
|Fluorourcil
 
|Fluoruracilo
 
|Fluoruracilo
 +
|-
 
|Fluoxan
 
|Fluoxan
 
|Flurablastin
 
|Flurablastin
−
|-
 
 
|Flurac
 
|Flurac
 
|Fluracedyl
 
|Fluracedyl
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|Fluroblastine
 
|Fluroblastine
 
|Ftoruracil
 
|Ftoruracil
 +
|-
 
|Ftouracil
 
|Ftouracil
−
|FU
 
−
|-
 
−
|FU Kyorin
 
−
|FU MI TE
 
−
|FU Schering
 
 
|Haemato-FU
 
|Haemato-FU
 
|Ifacil
 
|Ifacil
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|Kecimeton Tatumi
 
|Kecimeton Tatumi
 
|Killit
 
|Killit
 +
|Lunachol
 +
|Lunapon
 
|-
 
|-
−
|LA FU
 
−
|Lunachol DS Sawai
 
−
|Lunachol Yoshitomi
 
−
|Lunapon
 
 
|Natira U
 
|Natira U
 
|Neofluor
 
|Neofluor
 
|O Fluor
 
|O Fluor
 
|Oncofu
 
|Oncofu
−
|-
 
 
|Onkofluor
 
|Onkofluor
 
|Pentafu
 
|Pentafu
 
|Pharmauracil
 
|Pharmauracil
 
|Phthoruracil
 
|Phthoruracil
 +
|-
 
|Phtoruracil
 
|Phtoruracil
 
|Ribofluor
 
|Ribofluor
 
|Rotianin
 
|Rotianin
−
|Sanc F D
 
−
|-
 
 
|Satelol
 
|Satelol
 
|Seco Uracil
 
|Seco Uracil
 
|Tecflu
 
|Tecflu
 
|Timadin
 
|Timadin
−
|Timadin Dry
 
−
|Trav Fluorouracil
 
 
|Triosules
 
|Triosules
 +
|-
 
|Uflahex
 
|Uflahex
−
|-
 
 
|Ulosagen
 
|Ulosagen
−
|Ulup Maruko
+
|Ulup
−
|Ulup Mitsubishi
 
 
|Uraciflor
 
|Uraciflor
 
|Utoral
 
|Utoral
 
|Vaflu
 
|Vaflu
 
|Vafu
 
|Vafu
−
|Zhongren FU AN
 
 
|-
 
|-
 
|}
 
|}
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[[Category:Drug index]]
 
[[Category:Drug index]]
−
[[Category:Chemotherapy]]
 
 
[[Category:Intravenous medications]]
 
[[Category:Intravenous medications]]
 
[[Category:Topical medications]]
 
[[Category:Topical medications]]
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[[Category:Bladder cancer medications]]
 
[[Category:Bladder cancer medications]]
 
[[Category:Breast cancer medications]]
 
[[Category:Breast cancer medications]]
−
[[Category:Cancer of unknown primary medications]]
 
 
[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 +
[[Category:Cholangiocarcinoma medications]]
 
[[Category:Colon cancer medications]]
 
[[Category:Colon cancer medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Gastric cancer medications]]
 
[[Category:Gastric cancer medications]]
 
[[Category:Head and neck cancer medications]]
 
[[Category:Head and neck cancer medications]]
−
[[Category:Hepatobiliary cancer medications]]
+
[[Category:Hepatocellular carcinoma medications]]
−
[[Category:Neuroendocrine tumor medications]]
+
[[Category:Nasopharyngeal carcinoma medications]]
 
[[Category:Pancreatic cancer medications]]  
 
[[Category:Pancreatic cancer medications]]  
 +
[[Category:Pancreatic NET medications]]
 
[[Category:Penile cancer medications]]  
 
[[Category:Penile cancer medications]]  
 
[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Rectal cancer medications]]
 
[[Category:Rectal cancer medications]]
 +
[[Category:SCC of unknown primary medications]]
  
 
[[Category:Drugs FDA approved in 1962]]
 
[[Category:Drugs FDA approved in 1962]]
 
[[Category:WHO Essential Cancer Medicine]]
 
[[Category:WHO Essential Cancer Medicine]]

Revision as of 18:51, 21 January 2018

General information

Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).[1][2].
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

  • 4/25/1962: Initial FDA approval

Also known as

  • Generic names: 5 Fluorouracil, 5 FU, 5-fluoracilo, 5-fluorouracilo, 5-fluorouracyl, FU
  • Brand names:
Synonyms
Accusite Actino Hermal Adrucil Arumel Benton Biofur Carac Carebin
Carzonal Cinco-FU Cinkef-U Curacil Effcil Efudex Efurix Ezadex
Fauldfluor Fivocil Fivoflu Flacule Flonida Florac Fluhomer Fluolex
Fluoroplex Fluor-Uracil Fluoro-Uracile ICN Fluoro-Uracil ICN Fluorouracile Fluorouracilo Fluorourcil Fluoruracilo
Fluoxan Flurablastin Flurac Fluracedyl Fluracil Fluroblastin Fluroblastine Ftoruracil
Ftouracil Haemato-FU Ifacil Kang Ning Kecimeton Tatumi Killit Lunachol Lunapon
Natira U Neofluor O Fluor Oncofu Onkofluor Pentafu Pharmauracil Phthoruracil
Phtoruracil Ribofluor Rotianin Satelol Seco Uracil Tecflu Timadin Triosules
Uflahex Ulosagen Ulup Uraciflor Utoral Vaflu Vafu

References

  1. ↑ 1.0 1.1 Fluorouracil (5-FU) package insert (locally hosted backup)
  2. ↑ 5-FU pathway
  3. ↑ Fluorouracil (5-FU) patient drug information (Chemocare)
  4. ↑ Fluorouracil (5-FU) patient drug information (UpToDate)
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