Difference between revisions of "Epirubicin (Ellence)"
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| + | Also known as Epirubicin Ebewe. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[ | + | Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[[Media:Epirubicin.pdf | Epirubicin (Ellence) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] | <br>Extravasation: [[vesicant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Bone cancer]] | ||
| + | *[[Breast cancer]] | ||
| + | *[[Esophageal cancer]] | ||
| + | *[[Gastric cancer]] | ||
| + | *[[Hepatobiliary cancer]] | ||
| + | *[[Testicular cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/epirubicin.aspx Epirubicin (Ellence) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/epirubicin.aspx Epirubicin (Ellence) patient drug information (Chemocare)]</ref> |
| + | *Brief patient counseling information can be found on [http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf#page=15 pages 15-16 of the Epirubicin (Ellence) package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/epirubicin-patient-drug-information Epirubicin (Ellence) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:Anthracyclines]] | ||
| + | [[Category:Topoisomerase inhibitors]] | ||
| + | [[Category:DNA synthesis inhibitors]] | ||
| + | [[Category:Bone cancer medications]] | ||
| + | [[Category:Breast cancer medications]] | ||
| + | [[Category:Esophageal cancer medications]] | ||
| + | [[Category:Gastric cancer medications]] | ||
| + | [[Category:Hepatobiliary cancer medications]] | ||
| + | [[Category:Testicular cancer medications]] | ||
Revision as of 05:52, 15 October 2012
Also known as Epirubicin Ebewe.
General information
Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Epirubicin (Ellence) patient drug information (Chemocare)[3]
- Brief patient counseling information can be found on pages 15-16 of the Epirubicin (Ellence) package insert[1]
- Epirubicin (Ellence) patient drug information (UpToDate)[4]