Difference between revisions of "Enzalutamide (Xtandi)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Prostate cancer]] | *[[Prostate cancer]] | ||
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==Patient drug information== | ==Patient drug information== | ||
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==Also known as== | ==Also known as== | ||
| − | MDV3100 | + | *'''Code name:''' MDV3100 |
| + | *'''Brand name:''' Xtandi | ||
==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
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[[Category:Endocrine therapy]] | [[Category:Endocrine therapy]] | ||
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[[Category:Prostate cancer medications]] | [[Category:Prostate cancer medications]] | ||
[[Category:Drugs FDA approved in 2012]] | [[Category:Drugs FDA approved in 2012]] | ||
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Revision as of 15:47, 8 October 2017
General information
Class/mechanism: Antiandrogen; androgen receptor inhibitor (ARI) or androgen receptor signaling inhibitor (ARSI). Enzalutamide competitively inhibits testosterone from binding to the androgen receptor, interferes with translocation of the androgen receptor to the nucleus, and inhibits binding to DNA, resulting in decreased prostate cancer proliferation and cell death.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
Patient drug information
- Enzalutamide (Xtandi) package insert[1]
- Enzalutamide (Xtandi) patient drug information (Chemocare)[4]
- Enzalutamide (Xtandi) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 8/31/2012: Initial FDA approval "for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel."
- 9/10/2014: FDA approved "for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC)." (no longer needs to be after docetaxel)
Also known as
- Code name: MDV3100
- Brand name: Xtandi