Example orders for CapeOx (XELOX) in colon cancer

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CapeOx (XELOX)

CapeOX: Capecitabine, OXaliplatin
XELOX: XELoda, OXaliplatin

Original references may be found at CapeOx (XELOX) (adjuvant) & CapeOx (XELOX) (metastatic)

Example regimen #1

• Capecitabine (Xeloda) 1000 mg/m2 PO BID on days 1-14
• Oxaliplatin (Eloxatin) 130 mg/m2 IV over 2 hours on day 1
  • Mix in 500 mL D5W, and only infuse through D5W line.

21-day cycles x 8 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity

Supportive medications:

• Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy
• Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy
• Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start prior to oxaliplatin to decrease likelihood of neuropathy
• Calcium gluconate 1 g & magnesium sulfate 1 g (admixed together) IV, given over 30 minutes, to start after oxaliplatin infusion is complete to decrease likelihood of neuropathy

Hydration:

• 500 ml D5W at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml D5W.

Monitoring:

• Hold if ANC <1000 or platelets <100 and notify physician.

Comments:

• My institution uses the schedule described by Haller, et al. 2011.