Difference between revisions of "Gastric cancer"
Jump to navigation
Jump to search
(Created page with "'''Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.''' Is there...") |
m (formatting of headers) |
||
| Line 5: | Line 5: | ||
{{TOC limit|limit=3}} | {{TOC limit|limit=3}} | ||
| − | + | =Perioperative chemotherapy= | |
| − | + | ==ECF== | |
ECF: '''<u>E</u>'''pirubicin, '''<u>C</u>'''isplatin, '''<u>F</u>'''luorouracil | ECF: '''<u>E</u>'''pirubicin, '''<u>C</u>'''isplatin, '''<u>F</u>'''luorouracil | ||
| − | + | ===Regimen=== | |
| − | |||
*[[Epirubicin (Ellence)]] 50 mg/m2 IV on day 1 | *[[Epirubicin (Ellence)]] 50 mg/m2 IV on day 1 | ||
*[[Cisplatin (Platinol)]] 60 mg/m2 IV on day 1 | *[[Cisplatin (Platinol)]] 60 mg/m2 IV on day 1 | ||
| Line 20: | Line 19: | ||
*[[Warfarin (Coumadin)]] 1 mg PO daily suggested as thrombosis prophylaxis | *[[Warfarin (Coumadin)]] 1 mg PO daily suggested as thrombosis prophylaxis | ||
| − | + | ===References=== | |
# Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006 Jul 6;355(1):11-20. [http://www.nejm.org/doi/full/10.1056/NEJMoa055531 link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/16822992 PubMed] | # Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006 Jul 6;355(1):11-20. [http://www.nejm.org/doi/full/10.1056/NEJMoa055531 link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/16822992 PubMed] | ||
| − | + | =Adjuvant chemotherapy= | |
| − | + | ==Fluorouracil (5-FU) & Folinic acid (Leucovorin)== | |
| − | + | ===Regimen=== | |
Cycles 1, 3, 4: | Cycles 1, 3, 4: | ||
*[[Fluorouracil (5-FU)]] 425 mg/m2 IV bolus on days 1-5 | *[[Fluorouracil (5-FU)]] 425 mg/m2 IV bolus on days 1-5 | ||
| Line 39: | Line 38: | ||
'''35-day cycle x 1 cycle, to be followed by cycle 3 as described above''' | '''35-day cycle x 1 cycle, to be followed by cycle 3 as described above''' | ||
| − | + | ===References=== | |
# Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001 Sep 6;345(10):725-30. [http://www.nejm.org/doi/full/10.1056/NEJMoa010187 link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/11547741 PubMed] | # Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001 Sep 6;345(10):725-30. [http://www.nejm.org/doi/full/10.1056/NEJMoa010187 link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/11547741 PubMed] | ||
Revision as of 04:01, 21 April 2012
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.
Perioperative chemotherapy
ECF
ECF: Epirubicin, Cisplatin, Fluorouracil
Regimen
- Epirubicin (Ellence) 50 mg/m2 IV on day 1
- Cisplatin (Platinol) 60 mg/m2 IV on day 1
- Fluorouracil (5-FU) 200 mg/m2/day IV continuous infusion on days 1-21
- Surgery is performed 3-6 weeks after the completion of cycle 3
21-day cycles x 3 cycles prior to surgery, then 3 cycles to begin 6-12 weeks after surgery
Supportive medications:
- Warfarin (Coumadin) 1 mg PO daily suggested as thrombosis prophylaxis
References
- Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006 Jul 6;355(1):11-20. link to original article contains protocol PubMed
Adjuvant chemotherapy
Fluorouracil (5-FU) & Folinic acid (Leucovorin)
Regimen
Cycles 1, 3, 4:
- Fluorouracil (5-FU) 425 mg/m2 IV bolus on days 1-5
- Folinic acid (Leucovorin) 20 mg/m2 IV bolus on days 1-5
28-day cycles x 3 total cycles, interrupted by cycle 2 as described below
Cycle 2:
- Fluorouracil (5-FU) 400mg/m2 IV bolus on days 1-4 and the last 3 days of radiation therapy
- Folinic acid (Leucovorin) 20 mg/m2 IV bolus on days 1-4 and the last 3 days of radiation therapy
- Concurrent radiation therapy starting cycle 2 day 1 with 180 cGy, 5 days per week; 25 fractions given over 5 weeks for a total of 4500 cGy
35-day cycle x 1 cycle, to be followed by cycle 3 as described above
References
- Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001 Sep 6;345(10):725-30. link to original article contains protocol PubMed