Warfarin (Coumadin)

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General information

Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

Synonyms
Aldocumar Anasmol Anticoag APO-Warfarin Arefarin Athrombin-K Befarin Caumadin
Choice Cicoxil Circuvit Coumadin Coumadine Coumadin Sodium Couparin Dagonal
Farin Ferevan Fericard GEN-Warfarin Haemofarin Jantoven Kovar Lawarin
Maforan Marfarin Marivanil Marivarin Orfarin Panwarfin Panwarfine Romesa
Samofaron Samofaron Choseido Simarc Taro-Warfarin Tedicumar UNI-Warfine Uniwarfin Varfarins
Varfine Waran Warf Warfa Warfant Warfar Warfarex Warfarin
Warfarina Sodica Warfarin K Warfarin Potassium Warfarin Sodium Warfarin Sodium Almus Warfarin Sodium Arrow Warfarin Sodium Clathrate Warfarin Sodium Kent Pharm
Warfarin WBP Warfil Warfilone Warfin Warin Warlin Warnerin Werifrin

References

  1. 1.0 1.1 1.2 Warfarin (Coumadin) package insert
  2. Warfarin (Coumadin) package insert (locally hosted backup)
  3. Coumadin manufacturer's website
  4. Warfarin (Coumadin) patient drug information (UpToDate)