Neuroblastoma

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14 regimens on this page 15 variants on this page

Neuroblastoma is a rare cancer but is the most common malignancy of infancy. Most of our contributors are adult oncologists, please consider expanding this page!

High-risk

Dinutuximab, GM-CSF, IL-2, Isotretinoin

Regimen

Study	Evidence	Comparator	Efficacy
Yu et al. 2010 (COG ANBL0032)	Phase III	Isotretinoin	Seems to have superior OS

Note: in distinction from most chemotherapy regimens, the first day of a cycle is day 0 and the last day of a 28-day cycle is day 27.

Immunotherapy

• Dinutuximab (Unituxin) as follows:
  • Cycles 1, 3, 5: 25 mg/m² IV once per day on days 3 to 6
  • Cycles 2 & 4: 25 mg/m² IV once per day on days 7 to 10
• Sargramostim (Leukine) as follows:
  • Cycles 1, 3, 5: 250 μg/m² SC once per day on days 0 to 13
• Aldesleukin (Proleukin) as follows:
  • Cycles 2 & 4: 3.0 x 10⁶ IU/m²/day IV continuous infusion on days 0 to 3, then 4.5 x 10⁶ IU/m²/day IV continuous infusion on days 7 to 10
• Isotretinoin (Accutane) 160 mg/m²/day PO on days 14 to 27

28-day cycle for 6 cycles

References

1. Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, Shimada H, Grupp SA, Seeger R, Reynolds CP, Buxton A, Reisfeld RA, Gillies SD, Cohn SL, Maris JM, Sondel PM; Children's Oncology Group.. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010 Sep 30;363(14):1324-34. link to original article contains verified protocol PubMed

Isotretinoin (Accutane)

Regimen

Study	Evidence	Comparator	Efficacy
Yu et al. 2010 (COG ANBL0032)	Phase III	Dinutuximab, GM-CSF, IL-2, Isotretinoin	Seems to have inferior OS

Chemotherapy

• Isotretinoin (Accutane) 80 mg/m² BID on days 1 to 14

28-day cycle for 6 cycles

References

1. Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, Shimada H, Grupp SA, Seeger R, Reynolds CP, Buxton A, Reisfeld RA, Gillies SD, Cohn SL, Maris JM, Sondel PM; Children's Oncology Group.. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010 Sep 30;363(14):1324-34. link to original article contains verified protocol PubMed