Difference between revisions of "Pertuzumab (Perjeta)"
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==Clinical trials== | ==Clinical trials== | ||
| − | *[http://www.nejm.org/doi/full/10.1056/NEJMoa1113216 CLEOPATRA trial]<ref>Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, Clark E, Benyunes MC, Ross G, Swain SM; CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012 Jan 12;366(2):109-19. Epub 2011 Dec 7. [http://www.nejm.org/doi/full/10.1056/NEJMoa1113216 link to original article] [ | + | *[http://www.nejm.org/doi/full/10.1056/NEJMoa1113216 CLEOPATRA trial]<ref>Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, Clark E, Benyunes MC, Ross G, Swain SM; CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012 Jan 12;366(2):109-19. Epub 2011 Dec 7. [http://www.nejm.org/doi/full/10.1056/NEJMoa1113216 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/22149875 PubMed]</ref> |
| − | *[http://www.sciencedirect.com/science/article/pii/S1470204511703369 NeoSphere trial]<ref>Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 2012 Jan;13(1):25-32. Epub 2011 Dec 6. [http://www.sciencedirect.com/science/article/pii/S1470204511703369 link to original article] [ | + | *[http://www.sciencedirect.com/science/article/pii/S1470204511703369 NeoSphere trial]<ref>Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 2012 Jan;13(1):25-32. Epub 2011 Dec 6. [http://www.sciencedirect.com/science/article/pii/S1470204511703369 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/22153890 PubMed]</ref> |
==Patient drug information== | ==Patient drug information== | ||
Revision as of 03:14, 2 December 2016
General information
Class/mechanism: Humanized monoclonal antibody that binds to the extracellular dimerization subdomain II of HER2, preventing dimerization with other HER receptors (i.e. EGFR/HER1, HER3, and HER4). Pertuzumab inhibits ligand-initiated intracellular signaling via the MAP (mitogen-activated protein) kinase and PI3K (phosphoinositide 3-kinase) pathways, which results in cell growth arrest and apoptosis. Also stimulates antibody-dependent cell-mediated cytotoxicity (ADCC).[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert.[1]
Diseases for which it is used
Clinical trials
Patient drug information
- Pertuzumab (Perjeta) patient drug information (Chemocare)[6]
- Pertuzumab (Perjeta) patient drug information[7]
- Brief patient counseling information can be found on page 16 of the package insert[1]
- Pertuzumab (Perjeta) patient drug information (UpToDate)[8]
History of changes in FDA indication
- 6/8/2012: FDA approved "for use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease."
Also known as
2C4, Omnitarg, Rhumab 2C4.
References
- ↑ 1.0 1.1 1.2 Pertuzumab (Perjeta) package insert
- ↑ Pertuzumab (Perjeta) package insert (locally hosted backup)
- ↑ Perjeta manufacturer's website
- ↑ Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, Clark E, Benyunes MC, Ross G, Swain SM; CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012 Jan 12;366(2):109-19. Epub 2011 Dec 7. link to original article PubMed
- ↑ Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 2012 Jan;13(1):25-32. Epub 2011 Dec 6. link to original article PubMed
- ↑ Pertuzumab (Perjeta) patient drug information (Chemocare)
- ↑ Pertuzumab (Perjeta) patient drug information
- ↑ Pertuzumab (Perjeta) patient drug information (UpToDate)