Triptorelin (Trelstar LA)

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Also known as Decapeptyl, Diphereline, Gonapeptyl, or Variopeptyl.

General information

Class/mechanism: GnRH (gonadotropin-releasing hormone)/LHRH (luteinizing hormone releasing hormone) agonist; inhibits gonadotropin secretion, decreasing circulating levels of LH (luteinizing hormone) and FSH (follicle stimulating hormone), and suppressing synthesis of ovarian and testicular steroids.[1][2]
Route: IM
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 6/15/2000: Initial FDA approval "in the palliative treatment of advanced prostate cancer."


  1. 1.0 1.1 Triptorelin (Trelstar LA) package insert
  2. Triptorelin (Trelstar LA) package insert (locally hosted backup)
  3. Triptorelin (Trelstar LA) patient drug information (UpToDate)