Tivozanib (Fotivda)

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Mechanism of action

From the NCI Drug Dictionary: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.[1][2][3]

Diseases for which it is established (work in progress)

Patient drug information

History of changes in FDA indication

  • 2021-03-10: Approved for adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. (Based on TIVO-3)

History of changes in EMA indication

  • 2017-08-24: Initial authorization

Also known as

  • Code name: AV-951
  • Brand name: Fotivda