Tivozanib (Fotivda)

From HemOnc.org - A Hematology Oncology Wiki
(Redirected from Tivozanib (AV-951))
Jump to navigation Jump to search

Mechanism of action

From the NCI Drug Dictionary: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.[1][2][3]

Diseases for which it is used

Patient drug information

History of changes in FDA approval

  • 3/10/2021: Approved for adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies.

Also known as

  • Code name: AV-951
  • Brand name: Fotivda

References