Tarlatamab (Imdelltra)

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Mechanism of action

From the NCI Drug Dictionary: A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, tarlatamab binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the DLL3 antigen found on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells.

Diseases for which it is used

History of changes in FDA indication

  • 2024-05-16: Granted accelerated approval for extensive stage small cell lung cancer (ES-SCLC) with disease progression on or after platinum-based chemotherapy. (Based on DeLLphi-301)

Also known as

  • Code name: AMG-757
  • Brand name: Imdelltra