Class/mechanism from the NCI Drug Dictionary: A longer-acting antibody directed against terminal complement protein C5, with potential anti-inflammatory activity. Upon administration, ravulizumab-cwvz binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and preventing the complement-mediated destruction of red blood cells (RBCs) as seen in paroxysmal nocturnal hemoglobinuria (PNH). Compared to other anti-C5 antibodies, ALXN1210 is longer-acting and allows for monthly dosing.
Extravasation: no information
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Diseases for which it is used
History of changes in FDA indication
- 12/21/2018: Initial approval for adult patients with paroxysmal nocturnal hemoglobinuria (PNH). (Based on ALXN1210-PNH-301 & ALXN1210-PNH-302)
History of changes in EMA indication
- 7/2/2019: Initial authorization
Also known as
- Code name: ALXN1210
- Generic name: ravulizumab-cwvz
- Brand name: Ultomiris