Rasburicase (Elitek)

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General information

Class/mechanism: Recombinant urate-oxidase. Rasburicase catalyzes the enzymatic oxidation of poorly soluble uric acid into allantoin, an inactive and more soluble metabolite.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

History of changes in FDA indication

  • 7/12/2002: FDA approved "for initial management of plasma uric acid levels in pediatric and adult patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anti-cancer therapy expected to result in tumor lysis and subsequent elevation of plasma uric acid."[1]

Also known as

  • Brand names: Elitek, Fasturtec, Rasbelon, Rasburnat, Rasby

References

  1. 1.0 1.1 1.2 1.3 Rasburicase (Elitek) package insert
  2. Rasburicase (Elitek) package insert (locally hosted backup)
  3. Elitek manufacturer's website