Class/mechanism: Antimetabolite, inhibitor of thymidylate synthase. Raltitrexed is a quinazoline folate analog which inhibits thymidylate synthase (TS). TSis an enzyme involved in the synthesis of thymidine triphosphate (TTP), a nucleotide required exclusively for DNA synthesis. Inhibiting TS causes DNA damage and cell death.
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Patient drug information
No information available.
Diseases for which it is established (work in progress)
Diseases for which it is used
History of changes in EMA indication
- 1995-11-08: EURD
Also known as
- Code names: TDX, ZD-1694
- Generic name: raltitrexed disodium
- Brand name: Tomudex