Olverembatinib (HQP-1351)
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Mechanism of action
Third-generation TKI
Diseases for which it is used
History of changes in NMPA indication
- 2021-11: Initial conditional approval for the treatment of adult patients with TKI-resistant CML-CP or CML-AP harboring the T315I mutation as confirmed by a validated diagnostic test. (Based on HQP1351CC202 & HQP1351CC203)
- 2023-11-17: Approved for the treatment of adult patients with chronic-phase chronic myeloid leukemia (CML-CP) resistant and/or intolerant of first-and second-generation tyrosine kinase inhibitors (TKIs). (Based on HQP1351CC203)
Also known as
- Code name: HQP-1351