Class/mechanism: Long-acting octapeptide that suppresses multiple hormones and has physiologic actions similar to somatostatin. It suppresses LH response to GnRH, reduces splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, pancreatic polypeptide, growth hormone, IGF-I (somatomedin C), glucagon, insulin, and TSH.
Route: SC, IV
Extravasation: no information
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Diseases for which it is used
Patient drug information
- Octreotide (Sandostatin) patient drug information (Chemocare)
- Octreotide (Sandostatin) patient drug information (UpToDate)
History of changes in FDA indication
- 10/21/1988: Initial approval for treatment of chronic and severe diarrhea and flushing episodes associated with carcinoid tumors and vasoactive intestinal peptide-secreting tumors (VIPomas)
Also known as
- Code name: SMS 201-995
- Generic names: octreotide immediate release, octreotide IR, octreotide acetate
- Brand names: Longastatina, Octrestatin, Octride, Okeron, Proclose, Samilstin, Sandostatin, Sandostatina, Sandostatine