Nirogacestat (Ogsiveo)

Mechanism of action

From the NCI Drug Dictionary: A selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch.

Diseases for which it is used

• Desmoid tumor

History of changes in FDA indication

• 2023-11-27: Approved for adult patients with progressing desmoid tumors who require systemic treatment. (Based on DeFi)

Also known as

• Code name: PF-03084014
• Brand name: Ogsiveo