Mitotane (Lysodren)

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General information

Class/mechanism: Adrenal cytotoxic agent, suppresses adrenal cortex and the extra-adrenal metabolism of cortisol.[1][2]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

Also known as

  • Generic name: o,pā€²-DDD
  • Brand name: Lysodren


  1. ā†‘ 1.0 1.1 Mitotane (Lysodren) package insert
  2. ā†‘ Mitotane (Lysodren) package insert (locally hosted backup)
  3. ā†‘ Mitotane (Lysodren) patient drug information (UpToDate)