Lurbinectedin (Zepzelca)

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General information

Class/mechanism: Alkylator, binds to the minor groove of DNA, which distorts the DNA helix toward the major groove. This binding interrupts normal cell function and interferes with the expression of several several transcription factors, DNA binding proteins, and DNA repair mechanisms, which interrupts cell cycle and leads to tumor death.[1][2][3]
Route: IV
Extravasation: no information to cite, but suspected vesicant due to its similarity to Trabectedin (Yondelis)

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

History of changes in Health Canada indication

  • 2021-09-29: Initial notice of compliance with conditions for the treatment of adults with Stage III or metastatic small cell lung cancer (SCLC) who have progressed on or after platinum-containing therapy.

Also known as

  • Code name: PM-01183
  • Brand name: Zepzelca