Gallium Ga 68 gozetotide (Locametz)
Class/mechanism: Radioactive diagnostic agent for PET. The radionucleotide gallium-68 binds to PSMA (prostate-specific membrane antigen), a transmembrane protein that is expressed in prostate cancer, to allow detection of PSMA positive cells by PET. Gallium 68's half-life is 68 minutes.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 2020-12-01: FDA approved "for patients with suspected prostate cancer metastasis...who are potentially curable by surgery or radiation therapy. Ga 68 PSMA-11 is also indicated for patients with suspected prostate cancer recurrence based on elevated serum prostate-specific antigen (PSA) levels."
- 2022-03-23: FDA approved "for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer":
- with suspected metastasis who are candidates for initial definitive therapy.
- with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level
- for selection of patients with metastatic prostate cancer, for whom lutetium Lu 177 vipivotide tetraxetan PSMA-directed therapy is indicated.
History of changes in EMA indication
Also known as
- Generic names: Gallium 68 PSMA-11