Fostamatinib (Tavalisse)

From - A Hematology Oncology Wiki
Jump to navigation Jump to search

General information

Class/mechanism: Spleen tyrosine kinase (SYK) inhibitor. The main metabolite of fostamatinib is R406, which reduces antibody-mediated destruction of platelets. R406 also inhibits signal transduction of Fc-activating receptors and B-cell receptor.[1][2][3][4][5]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

History of changes in EMA indication

  • 2020-01-09: Initial authorization as Tavlesse

History of changes in Health Canada indication

  • 2020-11-19: Initial notice of compliance

History of changes in PMDA indication

  • 2022-12-23: Initial approval

Also known as

  • Code names: R-788, R-935788
  • Brand name: Tavalisse, Tavlesse


  1. 1.0 1.1 1.2 Fostamatinib (Tavalisse) package insert
  2. Fostamatinib (Tavalisse) package insert (locally hosted backup)
  3. Tavalisse manufacturer's website
  4. Podolanczuk A, Lazarus AH, Crow AR, Grossbard E, Bussel JB. Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk. Blood. 2009 Apr 2;113(14):3154-60. link to original article PubMed
  5. Newland A, Lee EJ, McDonald V, Bussel JB. Fostamatinib for persistent/chronic adult immune thrombocytopenia. Immunotherapy. 2018 Jan;10(1):9-25. link to original article PubMed