Forodesine (Fodosine)

Mechanism of action

From the NCI Drug Dictionary: The hydrochloride salt of the synthetic high-affinity transition-state analog forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes.

Diseases for which it is used

• Peripheral T-cell lymphoma

History of changes in PMDA indication

• 2017-03-30: Initial approval for the treatment of relapsed or refractory peripheral T-cell lymphoma.

Also known as

• Code name: BCX-1777
• Generic name: immucillin H
• Brand name: Fodosine, Mundesine