Ferric carboxymaltose (Injectafer)

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General information

Class/mechanism: Colloidal iron (III) hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

History of changes in FDA indication

  • 7/25/2013: FDA approved "for the treatment of iron deficiency anemia in adult patients:
    • who have intolerance to oral iron or have had unsatisfactory response to oral iron
    • who have non–dialysis-dependent chronic kidney disease."

References

  1. 1.0 1.1 1.2 Ferric carboxymaltose (Injectafer) package insert
  2. Ferric carboxymaltose (Injectafer) package insert (locally hosted backup)
  3. Injectafer manufacturer's website