Fadrozole (Afema)
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Mechanism of action
From the NCI Data Dictionary: The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers.
Diseases for which it is used
History of changes in PMDA indication
- 1995: Approved for the management of breast cancer.
Also known as
- Code name: CGS-16949A, FAD-286
- Brand name: Afema